IN THESE PAGES
12 good Vibrations
14 Where the Wild Things are
16 Kicking Carbon
Long a high-profit business,
the pharmaceutical industry has recently
shown some troubling symptoms.
Companies invest tons of money,
as well as years of research, trying to
develop game-changing blockbuster
drugs that, if successful, will deliver
phenomenal profits. But if they fail,
companies are left hemorrhaging mas-
sive amounts of time and money.
the unwieldy model is sparking
what John C. Lechleiter, phD, chair-
man, president and CEo of pharma-
ceutical giant Eli Lilly and Co., called
an “innovation crisis.” Writing in The
Wall Street Journal in July, he noted
that although research and develop-
ment (r&D) costs continue to rise,
fewer new drugs are gaining regulatory
approval in the United States.
one vaccination against stagnation
could be open source. first popular-
ized in software development, it lifted
the veil on coding, enabling multiple
developers to build off each other’s
ideas. a similar approach could let
drug companies break out of the devel-
opment doldrums—and help them
avoid repeating mistakes.
“for every step in the drug-development process, knowing what
doesn’t work is interesting, especially
when you are working with limited
funds,” says James McKerrow, phD,
MD, director of the Sandler Center for
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